The 53-year-old filmmaker claimed he used Madea to honour "the people that made me who I am."
He discussed Spike's comments on Chris Wallace's new HBO Max show.
Spike, 65, criticised Madea in 2009 for promoting harmful black stereotypes.
Perry said, "I've enjoyed my movies because they depict the folks I grew up with."
"Most of them didn't have a 12th-grade education, but their stories and how much they loved one other, and when they'd become sad, another would come in and make a joke
'I'm five years old, I'm on the floor with my matchbox cars, I'm in a masterclass for my life.'"
"When someone says, 'You're harkening back to a moment in our lives we don't want to talk about or we don't want the world to see,' you're disregarding the tales of millions and millions of black people.
What's important to me is honouring the individuals who taught and made me who I am."
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